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Chemical Structure : Sivopixant
CAS No.: 2414285-40-6
Catalog No.: PC-72666Not For Human Use, Lab Use Only.
Sivopixant (S-600918) is a potent and selective P2X3 homotrimers antagonist with IC50 of 4.2 nM, 250-fold selectivity over P2X2/3 heterotrimer (IC50=1,100 nM).
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Sivopixant (S-600918) is a potent and selective P2X3 homotrimers antagonist with IC50 of 4.2 nM, 250-fold selectivity over P2X2/3 heterotrimer (IC50=1,100 nM).
Sivopixant (S-600918) showed excellent profiles, potent analgesic effect, excellent absorbability and balanced PK profile.
| M.Wt | 507.931 | |
| Formula | C25H22ClN5O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S,E)-3-(3-(4-chlorobenzyl)-2,6-dioxo-4-((4-(pyridin-2-yloxy)phenyl)imino)-1,3,5-triazinan-1-yl)-2-methylpropanoic acid |
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1. Hiroyuki Kai, et al. Bioorg Med Chem Lett. 2021 Nov 15;52:128384.
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