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Solcitinib

Chemical Structure : Solcitinib

CAS No.: 1206163-45-2

Solcitinib (GSK-2586184, GLPG-0778, GSK2586184, GLPG0778)

Catalog No.: PC-45072Not For Human Use, Lab Use Only.

Solcitinib (GSK2586184, GLPG0778) is a potent, selective and orally active JAK1 inhibitor with IC50 of 9.8 nM.

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5 mg (Free Sample) $28 In stock
25 mg $158 In stock
50 mg $238 In stock
100 mg $388 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Solcitinib (GSK2586184, GLPG0778) is a potent, selective and orally active JAK1 inhibitor with IC50 of 9.8 nM.
Solcitinib (GSK2586184, GLPG0778) displays 11-, 55- and 23-fold selectivity over JAK2, JAK3 and TYK2, respectively.
Solcitinib (GSK2586184, GLPG0778) shows potential for the treatment of psoriasis, lupus, and ulcerative colitis.

Physicochemical Properties

M.Wt 389.4503
Formula C22H23N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 20 mg/mL

Chemical Name/SMILES

Cyclopropanecarboxamide, N-[5-[4-[(3,3-dimethyl-1-azetidinyl)carbonyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-

References

1. Ludbrook VJ, et al. Br J Dermatol. 2016 May;174(5):985-95. 

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