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Spautin-1

Chemical Structure : Spautin-1

CAS No.: 1262888-28-7

Spautin-1 (Spautin1)

Catalog No.: PC-62189Not For Human Use, Lab Use Only.

Spautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74 uM, inhibits USP10 and USP13 with IC50 of 0.6-0.7 uM, but not USP14.

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Biological Activity

Spautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74 uM, inhibits USP10 and USP13 with IC50 of 0.6-0.7 uM, but not USP14.
Spautin-1 promotes cell death under starvation condition and inhibits autophagic cell death, selectively promotes the degradation of Vps34 complexes, reduces the levels of PtdIns3P in cells, but is not a direct inhibitor of class III PI3 kinase activity.
Spautin-1 promotes the degradation of p53 via inhibition of USP10, which can be inhibited in the presence of MG132.
Spautin-1 sensitizes ovarian cancer cells to cisplatin and PARP inhibitor (olaparib).

Physicochemical Properties

M.Wt 271.271
Formula C15H11F2N3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine

References

1. Liu J, et al. Cell. 2011 Sep 30;147(1):223-34.

2. Li Y, et al. Nat Commun. 2017 Jun 1;8:15752. doi: 10.1038/ncomms15752.

3. Mateo R, et al. J Virol. 2013 Feb;87(3):1312-21.

4. Vakifahmetoglu-Norberg H, et al. Genes Dev. 2013 Aug 1;27(15):1718-30.

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