Stauprimide |CAS:154589-96-5‎ Probechem Biochemicals

Chemical Structure : Stauprimide

CAS No.: 154589-96-5‎

Stauprimide (N-Benzoyl-7-oxo Staurosporine)

Catalog No.: PC-70283Not For Human Use, Lab Use Only.

Stauprimide (N-Benzoyl-7-oxo Staurosporine) is a staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2, which in turn results in down-regulation of MYC transcription.

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Biological Activity

Stauprimide (N-Benzoyl-7-oxo Staurosporine) is a staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2, which in turn results in down-regulation of MYC transcription.
Stauprimide increases the efficiency of mouse and human embryonic stem cell differentiation in conjunction with lineage specification cues with EC50 of 0.3 uM.

Physicochemical Properties

M.Wt	584.6
Formula	C35H28N4O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((5R,7R,8R,9S)-8-methoxy-9-methyl-14,16-dioxo-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide

References

1. Bouvard C, et al. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3497-3502.

2. Zhu S, et al. Cell Stem Cell. 2009 May 8;4(5):416-26.

3. Tahamtani Y, et al. Stem Cells Dev. 2013 May 1;22(9):1419-32.

Stauprimide (N-Benzoyl-7-oxo Staurosporine)

Biological Activity

Physicochemical Properties

References

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