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Chemical Structure : Stauprimide
CAS No.: 154589-96-5
Catalog No.: PC-70283Not For Human Use, Lab Use Only.
Stauprimide (N-Benzoyl-7-oxo Staurosporine) is a staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2, which in turn results in down-regulation of MYC transcription.
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Stauprimide (N-Benzoyl-7-oxo Staurosporine) is a staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2, which in turn results in down-regulation of MYC transcription.
Stauprimide increases the efficiency of mouse and human embryonic stem cell differentiation in conjunction with lineage specification cues with EC50 of 0.3 uM.
| M.Wt | 584.6 | |
| Formula | C35H28N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((5R,7R,8R,9S)-8-methoxy-9-methyl-14,16-dioxo-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide |
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1. Bouvard C, et al. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3497-3502.
2. Zhu S, et al. Cell Stem Cell. 2009 May 8;4(5):416-26.
3. Tahamtani Y, et al. Stem Cells Dev. 2013 May 1;22(9):1419-32.
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