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Staurosporine

Chemical Structure : Staurosporine

CAS No.: 62996-74-1

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Staurosporine (STS, AM-2282, Antibiotic AM-2282)

Catalog No.: PC-23471Not For Human Use, Lab Use Only.

Staurosporine (STS) is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Staurosporine (STS) is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively.
Staurosporine also inhibits TAOK2 with an IC50 of 3 μM.
Staurosporine is a classical apoptosis inducer.

Physicochemical Properties

M.Wt 466.54
Formula C28H26N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(5S,6R,7R,9R)-6-Methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14-one

References

1. Meggio F, et al. Eur J Biochem. 1995 Nov 15;234(1):317-22.

2. Yoshizawa S, et al. Cancer Res. 1990 Aug 15;50(16):4974-8.

3. Nabeshima T, et al. J Pharmacol Exp Ther. 1991 May;257(2):562-6.

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