Chemical Structure : Stavudine
CAS No.:
3056-17-5
Stavudine
(d4T)
Catalog No.: PC-28305Not For Human Use, Lab Use Only.
Stavudine (d4T) is a nucleoside reverse transcriptase inhibitor (NRTI), inhibits HIV-1 reverse transcriptase, also blocks NLRP3 inflammasome activation.
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Purity & Documentation Purity:
>98% (HPLC)
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Biological Activity
Stavudine (d4T) is a nucleoside reverse transcriptase inhibitor (NRTI), inhibits HIV-1 reverse transcriptase, also blocks NLRP3 inflammasome activation.
Stavudine (d4T) inhibits LPS/ATP-induced Caspase-1 maturation in primary mouse bone marrow-derived macrophages.
Stavudine (d4T) specifically inhibits P2X7-dependent inflammasome activation.
Stavudine (d4T) reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy.
Physicochemical Properties
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M.Wt
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224.22
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Formula
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C10H12N2O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-((2R,5S)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
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References
1. Moyle GJ, et al. Antivir Ther. 1997;2(4):207-218.
2. Riddler SA, et al. Antiviral Res. 1995;27(3):189-203.
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