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Steroid sulfatase inhibitor DU-14

Chemical Structure : Steroid sulfatase inhibitor DU-14

CAS No.: 186303-55-9

Steroid sulfatase inhibitor DU-14

Catalog No.: PC-23217Not For Human Use, Lab Use Only.

Steroid sulfatase inhibitor DU-14 is a hihly potent steroid sulfatase inhibitor with IC50 of 55.8 nM, inhibits inhibits the MCF-7 cell proliferation with IC50 of 38.7 nM.

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Biological Activity

Steroid sulfatase inhibitor DU-14 is a hihly potent steroid sulfatase inhibitor with IC50 of 55.8 nM, inhibits inhibits the MCF-7 cell proliferation with IC50 of 38.7 nM.
DU-14 shows neuroprotective effects against neurotoxic Aβ, alleviates Aβ-induced impairments in spatial memory and synaptic plasticity.
DU-14 can potentiate the blockade of the amnestic effects of scopolamine by exogenously administered DHEAS.
DU-14 enhanced the reversal of amnesia by DHEAS.

Physicochemical Properties

M.Wt 426.62
Formula C22H38N2O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[2-[4-[(Aminosulfonyl)oxy]phenyl]ethyl]tetradecanamide

References

1. Li PK, et al. Life Sci. 1997;60(3):PL45-51.

2. Johnson DA, et al. Life Sci. 1997;61(24):PL 355-9.

3. Selcer KW, et al. Cancer Res. 1997 Feb 15;57(4):702-7.

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