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Strontium ranelate

Chemical Structure : Strontium ranelate

CAS No.: 135459-87-9

Strontium ranelate (Distrontium renelate;S-12911)

Catalog No.: PC-45220Not For Human Use, Lab Use Only.

A strontium(II) salt of ranelic acid that stimulates CaSR and leads to the differentiation of pre-osteoblast to osteoblast, increases the bone formation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A strontium(II) salt of ranelic acid that stimulates CaSR and leads to the differentiation of pre-osteoblast to osteoblast, increases the bone formation; also stimulates osteoblasts to secrete osteoprotegerin in inhibiting osteoclasts formed from pre-osteoclasts in relation to the RANKL system; a medication for osteoporosis treatment.

Osteoporosis

Approved

Physicochemical Properties

M.Wt 513.4896
Formula C12H6N2O8SSr2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: < 1 mg/mL

Chemical Name/SMILES

3-Thiopheneacetic acid, 5-[bis(carboxymethyl)amino]-2-carboxy-4-cyano-, strontium salt (1:2)

References

1. Hamdy NA. Rheumatology (Oxford). 2009 Oct;48 Suppl 4:iv9-13.

2. Chu JG, et al. BMC Musculoskelet Disord. 2017 Feb 10;18(1):78.

3. Tsai TT, et al. PLoS One. 2017 Jan 4;12(1):e0167296.

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