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Subquinocin

Chemical Structure : Subquinocin

CAS No.: 1093413-93-4

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Subquinocin

Catalog No.: PC-73355Not For Human Use, Lab Use Only.

Subquinocin is a small molecule inhibitor of DUB activity of CYLD with IC50 of 30 uM, enhances NF-κB activation by inhibiting CYLD.

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    Biological Activity

    Subquinocin is a small molecule inhibitor of DUB activity of CYLD with IC50 of 30 uM, enhances NF-κB activation by inhibiting CYLD.
    Subquinocin inhibits the DUB activity of CYLD by disturbing the interaction between the scissile bond of ubiquitin and catalytic cysteine residue (C598) of CYLD.
    Subquinocin also inhibits the DUB activities of USP5 and USP15.
    Subquinocin enhanced NF-κB activation by increasing polyubiquitin chains in cells.
    Subquinocin is an inhibitor for USP-family but not other families.

    Physicochemical Properties

    M.Wt 405.513
    Formula C20H27N3O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    methyl ((2-isobutyl-1-oxo-1,2-dihydroisoquinolin-4-yl)carbamoyl)methioninate

    References

    1. Yamanaka S, et al. Biochem Biophys Res Commun. 2020 Mar 26;524(1):1-7.

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