Succinyl phosphonate is an α-Ketoglutarate phosphoanalogue, α-ketoglutarate dehydrogenase (alpha-KGDHC) inhibitor, effectively inhibits α-ketoglutarate oxidative decarboxylation.
Succinyl phosphonate inhibits both muscle and bacterial α-ketoglutarate dehydrogenase complexes (KGDHC), as well as muscle alpha-ketoglutarate dehydrogenase.
Succinyl phosphonate inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ; impairs viability of cancer cells in a cell-specific metabolism-dependent manner.
Physicochemical Properties
M.Wt
182.0685
Formula
C4H7O6P
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Butanoic acid, 4-oxo-4-phosphono-
References
1. Biryukov AI, et al. FEBS Lett. 1996 Mar 11;382(1-2):167-70.
2. Bunik VI, et al. Biochemistry. 2005 Aug 9;44(31):10552-61.
3. Zündorf G, et al. Neuroscience. 2009 Jan 23;158(2):610-6.
4. Bunik VI, et al. Oncotarget. 2016 May 3;7(18):26400-21.
