Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Succinyl phosphonate
Catalog No.: PC-43150Not For Human Use, Lab Use Only.
Succinyl phosphonate is an α-Ketoglutarate phosphoanalogue, α-ketoglutarate dehydrogenase inhibitor, effectively inhibits α-ketoglutarate oxidative decarboxylation.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Succinyl phosphonate is an α-Ketoglutarate phosphoanalogue, α-ketoglutarate dehydrogenase (alpha-KGDHC) inhibitor, effectively inhibits α-ketoglutarate oxidative decarboxylation.
Succinyl phosphonate inhibits both muscle and bacterial α-ketoglutarate dehydrogenase complexes (KGDHC), as well as muscle alpha-ketoglutarate dehydrogenase.
Succinyl phosphonate inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ; impairs viability of cancer cells in a cell-specific metabolism-dependent manner.
| M.Wt | 182.0685 | |
| Formula | C4H7O6P | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Biryukov AI, et al. FEBS Lett. 1996 Mar 11;382(1-2):167-70.
2. Bunik VI, et al. Biochemistry. 2005 Aug 9;44(31):10552-61.
3. Zündorf G, et al. Neuroscience. 2009 Jan 23;158(2):610-6.
4. Bunik VI, et al. Oncotarget. 2016 May 3;7(18):26400-21.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
