Sulforaphane (SFN) is an antioxidant agent that exerts protective effects against cell damage by activating Nrf2.
Sulforaphane protects RLE‑6TN cells from oxidative damage, potentially via increasing Nrf2 expression and reducing ROS levels.
Sulforaphane reduces lens epithelial cell growth, migration and viability, and promotes ER stress and autophagy in lens cells.
Sulforaphane also inhibits class I and II HDAC activity and suppresses tumor growth by inducing cell cycle arrest and apoptosis selectively in various cancerous prostate epithelial cells without affecting normal cells.
Physicochemical Properties
M.Wt
177.28
Formula
C6H11NOS2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1-isothiocyanato-4-(methylsulfinyl)-butane
References
1. Jiao Z, et al. Mol Med Rep. 2017 Jun 6.
2. Kim SH, et al. Oncol Lett. 2017 Jun;13(6):4427-4432.
3. Liu H, et al. J Mol Med (Berl). 2017 May;95(5):553-564.
