Catalog No.: PC-46930Not For Human Use, Lab Use Only.
Suramin (BAY-205, NF-060) is an antitrypansomal drug that also possesses antitumor activity, inhibits CRL (Cullin-RING E3 ubiquitin ligases) activity by disrupting its ability to recruit Cdc34.
Suramin (BAY-205, NF-060) is an antitrypansomal drug that also possesses antitumor activity, inhibits CRL (Cullin-RING E3 ubiquitin ligases) activity by disrupting its ability to recruit Cdc34.
Suramin also potently inhibits sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM).
Suramin induces accumulation of CRL substrates.
Suramin also inhibits multiple viruses (ZIKVs, EV71).
