Syn-TEF1 |CAS:2135880-19-0 Probechem Biochemicals

Chemical Structure : Syn-TEF1

Syn-TEF1

Catalog No.: PC-63447Not For Human Use, Lab Use Only.

Syn-TEF1 is a molecule actively enables transcription across repressive GAA repeats that silence frataxin expression in Friedreich's ataxia, license transcription elongation at targeted genomic loci.

Packing	Price	Stock	Quantity
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

Syn-TEF1 is a molecule actively enables transcription across repressive GAA repeats that silence frataxin expression in Friedreich's ataxia, license transcription elongation at targeted genomic loci.
Syn-TEF1 targets the DNA sequence 5'-AAGAAGAAG-3', activate FXN expression in primary patient cells and patient-derived fibroblasts, iPSCs, cardiomyocytes, sensory neurons, and mouse xenografts.

Physicochemical Properties

M.Wt	1675.334
Formula	C77H104ClN23O16S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(5-((3-((2-((1-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-29-methyl-2,24,34-trioxo-6,9,12,15,18,-hexaoxa-3,25,29,33-tetraazahexatriacontan-36-yl)carbamoyl)-1-methyl-1H-imidazol-4-yl)amino)-3-oxoprop

References

1. Erwin GS, et al. Science. 2017 Dec 22;358(6370):1617-1622.

Syn-TEF1

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.