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Chemical Structure : Syn-TEF1
Catalog No.: PC-63447Not For Human Use, Lab Use Only.
Syn-TEF1 is a molecule actively enables transcription across repressive GAA repeats that silence frataxin expression in Friedreich's ataxia, license transcription elongation at targeted genomic loci.
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Syn-TEF1 is a molecule actively enables transcription across repressive GAA repeats that silence frataxin expression in Friedreich's ataxia, license transcription elongation at targeted genomic loci.
Syn-TEF1 targets the DNA sequence 5'-AAGAAGAAG-3', activate FXN expression in primary patient cells and patient-derived fibroblasts, iPSCs, cardiomyocytes, sensory neurons, and mouse xenografts.
| M.Wt | 1675.334 | |
| Formula | C77H104ClN23O16S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Erwin GS, et al. Science. 2017 Dec 22;358(6370):1617-1622.
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