T-025 | Probechem Biochemicals

Chemical Structure : T-025

CAS No.: 2407433-00-3

T-025 (T025;CLK inhibitor T-025)

Catalog No.: PC-35047Not For Human Use, Lab Use Only.

T-025 (T025, CLK inhibitor T-025) is an orally available, potent inhibitor of Cdc2-like kinases (CLKs) with Kd of 4.8, 0.096, 6.5, and 0.61 nM for CLK1, CLK2, CLK3, and CLK4, also inhibits DYRK1A and DYRK1B with IC50 of 0.074 and 1.5 nM.

Packing	Price	Stock
2 mg	$198	In stock
5 mg	$298	In stock
10 mg	$458	In stock
25 mg	$758	In stock
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Biological Activity

T-025 (T025, CLK inhibitor T-025) is an orally available, potent inhibitor of Cdc2-like kinases (CLKs) with Kd of 4.8, 0.096, 6.5, and 0.61 nM for CLK1, CLK2, CLK3, and CLK4, also inhibits DYRK1A and DYRK1B with IC50 of 0.074 and 1.5 nM.
T-025 (T025, CLK inhibitor T-025) reduces CLK-dependent phosphorylation, induces skipping exon, resulting in anti-proliferative effect in MDA-MB-468 in vitro and in vivo accompanied by the modulation of pre-mRNA splicing.
T-025 (T025, CLK inhibitor T-025) shows sensitivity against high CLK2 expression or MYC amplification cancer celles.
T-025 (T025, CLK inhibitor T-025) exhibits significant anti-tumor efficacy in MYC-driven breast tumor allograft models.

Physicochemical Properties

M.Wt	382.431
Formula	C21H18N8
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N2-methyl-N4-(pyrimidin-2-ylmethyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

References

1. Iwai K, et al. EMBO Mol Med. 2018 May 16. pii: e8289.

T-025 (T025;CLK inhibitor T-025)

Biological Activity

Physicochemical Properties

References

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