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Chemical Structure : T-1101 tosylate
CAS No.: 2250404-95-4
Catalog No.: PC-20310Not For Human Use, Lab Use Only.
T-1101 tosylate (TAI-95 tosylate) is a potent, orally abioavailable Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=14.29-73.65 nM, breast cancer cell lines).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $478 | In stock | |
| 250 mg | Get quote |
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T-1101 tosylate (TAI-95 tosylate) is a potent, orally abioavailable Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=14.29-73.65 nM, breast cancer cell lines).
T-1101 tosylate demonstrates strong inhibition of in vivo tumor growth of breast cancer models without inducing weight loss or other obvious toxicity.
T-1101 tosylate induces apoptotic cell death, shows activity on MDR cell lines and leads to downregulation of the expression of P-glycoprotein (Pgp),.
T-1101 tosylate also increases the potency of cytotoxic Pgp substrates, including doxorubicin and topotecan.
T-1101 tosylate showed promise in antitumor activity in mice bearing human tumor xenografts of liver cancer (Huh-7), as well as of breast cancer (BT474, MDA-MB-231, and MCF7) with oral administration.
| M.Wt | 665.80 | |
| Formula | C31H31N5O6S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-[4-(4-{[5-(2-methoxyethoxy)pyrazine-2-yl]thio}-2,6-dimethylphenyl) thiazol-2-yl]isonicotinamide tosylate |
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1. Huang LY, et al. Mol Cancer Ther. 2014 Jun;13(6):1419-30.
2. Chuang SH, et al. Eur J Med Chem. 2020 Apr 1;191:112118.
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