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T-3364366

Chemical Structure : T-3364366

CAS No.: 1356354-09-0

T-3364366 (T 3364366;T3364366)

Catalog No.: PC-61037Not For Human Use, Lab Use Only.

T-3364366 is a potent, selective and orally available inhibitor of delta-5 desaturase (D5D) with Ki of <2.7 nM and IC50 of 19 nM, with excellent selectivity over D6D and SCD.

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Biological Activity

T-3364366 is a potent, selective and orally available inhibitor of delta-5 desaturase (D5D) with Ki of <2.7 nM and IC50 of 19 nM, with excellent selectivity over D6D and SCD.
T-3364366 potently inhibits arachidonic acid (AA) production in liver cell lines derived from human (HepG2) and rat (RLN-10) with IC50 of 1.9 and 2.1 nM, respectively.
T-3364366 exhibits a reversible, slow-binding interaction to the desaturase domain of D5D.

Physicochemical Properties

M.Wt 443.459
Formula C18H16F3N3O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2-((4-oxo-3-(4-(2,2,2-trifluoroethoxy)phenyl)-3,4-dihydrothieno[3,4-d]pyrimidin-2-yl)thio)ethyl)acetamide

References

1. Miyahisa I, et al. ACS Med Chem Lett. 2016 Aug 10;7(9):868-72.

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