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T-3861174

Chemical Structure : T-3861174

CAS No.: 2209057-94-1

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T-3861174 (T3861174)

Catalog No.: PC-63354Not For Human Use, Lab Use Only.

T-3861174 is a small molecule prolyl tRNA synthetase (PRS) inhibitor with binding IC50 of 2.3 nM.

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    Biological Activity

    T-3861174 is a small molecule prolyl tRNA synthetase (PRS) inhibitor with binding IC50 of 2.3 nM.
    T-3861174 induces cell death in several tumor cell lines including SK-MEL-2 (IC50=0.1 uM) without complete suppression of translation, T-3861174-induced cell death was caused by activation of the GCN2-ATF4 pathway.
    T-3861174 exhibits significant tumor growth inhibition in SK-MEL-2, G-361, and HT-1080 xenograft models without severe body weight losses.

    Physicochemical Properties

    M.Wt 472.524
    Formula C26H25FN6O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-4-(3-cyano-3-cyclopropyl-2-oxopyrrolidin-1-yl)-N-(3-fluoro-5-(1-methyl-1H-pyrazol-4-yl)benzyl)-6-methylpicolinamide

    References

    1. Arita T, et al. Biochem Biophys Res Commun. 2017 Jul 8;488(4):648-654.

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