Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : T-3861174
Catalog No.: PC-63354Not For Human Use, Lab Use Only.
T-3861174 is a small molecule prolyl tRNA synthetase (PRS) inhibitor with binding IC50 of 2.3 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
T-3861174 is a small molecule prolyl tRNA synthetase (PRS) inhibitor with binding IC50 of 2.3 nM.
T-3861174 induces cell death in several tumor cell lines including SK-MEL-2 (IC50=0.1 uM) without complete suppression of translation, T-3861174-induced cell death was caused by activation of the GCN2-ATF4 pathway.
T-3861174 exhibits significant tumor growth inhibition in SK-MEL-2, G-361, and HT-1080 xenograft models without severe body weight losses.
| M.Wt | 472.524 | |
| Formula | C26H25FN6O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Arita T, et al. Biochem Biophys Res Commun. 2017 Jul 8;488(4):648-654.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
