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Chemical Structure : T0070907
CAS No.: 313516-66-4
Catalog No.: PC-43387Not For Human Use, Lab Use Only.
T0070907 is a potent, selective, covalent PPARγ antagonist with binding IC50 of 1 nM, >800-fold preference for PPARγ over PPARα and PPARδ.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $118 | In stock | |
| 50 mg | $188 | In stock | |
| 100 mg | $298 | In stock | |
| 250 mg | Get quote |
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T0070907 is a potent, selective, covalent PPARγ antagonist with binding IC50 of 1 nM, >800-fold preference for PPARγ over PPARα and PPARδ.
T0070907 specifically blocks PPARγ function in both cell-based reporter gene and adipocyte differentiation assays, with no effect on FXR, LXR, PR.
T0070907 modulates the interaction of PPARγ with cofactor proteins by affecting the conformation of helix 12 of the PPARγ ligand-binding domain (LBD).
T0070907 significantly more efficient at causing cancer cell death than the activators troglitazone and rosiglitazone.
| M.Wt | 277.6632 | |
| Formula | C12H8ClN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Benzamide, 2-chloro-5-nitro-N-4-pyridinyl- |
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1. Lee G, et al. J Biol Chem. 2002 May 31;277(22):19649-57.
2. Schaefer KL, et al. Cancer Res. 2005 Mar 15;65(6):2251-9.
3. Masuda T, et al. Clin Cancer Res. 2005 Jun 1;11(11):4012-21.
4. Zaytseva YY et al. Anticancer Res. 2011, 31(3), 813-823.
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