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T1551

Chemical Structure : T1551

CAS No.: 913691-90-4

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T1551 (T 1551;T-1551)

Catalog No.: PC-63538Not For Human Use, Lab Use Only.

T1551 is a novel, potent and specific PRMT5 inhibitor with IC50 of 34.1 uM, exhibits anti-proliferation on A549 cell with IC50 of 11.2 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    T1551 is a potent and specific PRMT5 inhibitor with IC50 of 34.1 uM, exhibits anti-proliferation on A549 cell with IC50 of 11.2 uM.
    T1551 reduces symmetric dimethylation level of H4R3, downregulates the protein expressions of two target genes of PRMT5, FGFR3, and eIF4E.
    T1551 inhibits the activation of PI3K/AKT/mTOR and ERK signaling.

    Physicochemical Properties

    M.Wt 302.401
    Formula C16H24N5O+
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((E)-amino(2-(((Z)-5-(hydroxymethyl)-3H-indol-3-ylidene)methyl)hydrazinyl)methylene)pentan-1-aminium

    References

    1. Wang Q, et al. Front Pharmacol. 2018 Mar 1;9:173.

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