T16Ainh-A01 | TMEM16A inhibitor | Probechem Biochemicals

Chemical Structure : T16Ainh-A01

CAS No.: 552309-42-9

T16Ainh-A01 (TMEM16A inhibitor)

Catalog No.: PC-35990Not For Human Use, Lab Use Only.

T16Ainh-A01 is an inhibitor of the calcium-activated chloride channel TMEM16A, inhibits Ca2+-activated Cl− channel (CACC) activity in TMEM16A-transfected FRT cells with IC50 of 1 uM.

Packing	Price	Stock
5 mg	$78	In stock
10 mg	$118	In stock
25 mg	$218	In stock
50 mg	$358	In stock
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Biological Activity

T16Ainh-A01 is an inhibitor of the calcium-activated chloride channel TMEM16A, inhibits Ca2+-activated Cl− channel (CACC) activity in TMEM16A-transfected FRT cells with IC50 of 1 uM.
T16Ainh-A01 (1-30 uM) inhibited single calcium (Ca2+)-activated chloride (Cl−) channels and whole cell currents activated by 500 nM free Ca2+.
T16Ainh-A01 relaxed mouse thoracic aorta pre-contracted with methoxamine with an IC50 of 1.6 uM and suppressed the methoxamine concentration-effect curve.
T16Ainh-A01 blocks calcium-activated chloride channels in vascular smooth muscle cells and relaxes murine and human blood vessels.

Physicochemical Properties

M.Wt	416.514
Formula	C19H20N4O3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide

References

1. Davis AJ, et al. Br J Pharmacol. 2013 Feb;168(3):773-84.

2. Mazzone A, et al. Biochem Biophys Res Commun. 2012 Oct 19;427(2):248-53.

3. Forrest AS, et al. Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1229-43.

4. Namkung W, et al. J Biol Chem. 2011 Jan 21;286(3):2365-74.