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T3D-959

Chemical Structure : T3D-959

CAS No.: 1258076-66-2

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T3D-959 (T3D959, DB-959, DB 959 sodium)

Catalog No.: PC-61599Not For Human Use, Lab Use Only.

T3D 959 (DB-959) is a potent, brain penetrant, orally active dual PPARδ/PPARγ agonist with EC50 of 19/297 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

T3D 959 (DB-959) is a potent, brain penetrant, orally active dual PPARδ/PPARγ agonist with EC50 of 19/297 nM, respectively.
T3D 959 (DB-959)  prevents STZ-induced neurotoxicity, and shows clear therapeutic and neuroprotective effects in an established model of sporadic AD.

Physicochemical Properties

M.Wt 443.47
Formula C25H26NNaO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

sodium 2-(5-(2-(5-ethyl-2-(4-methoxyphenyl)oxazol-4-yl)ethoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid

References

1. Tong M, et al. J Alzheimers Dis. 2016;51(1):123-38.

2. Tong M, et al. J Alzheimers Dis Parkinsonism. 2016 Jun;6(3). pii: 238.

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