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Chemical Structure : T417
CAS No.: 2032123-28-5
Catalog No.: PC-72727Not For Human Use, Lab Use Only.
T417 (PBX1 inhibitor T417, TCRS-417) is a novel small molecule compound capable of docking to the interface between PBX1 and its cognate DNA target sequence, potently interferes with the PBX1-DNA interaction with IC50 of 6.58 uM.
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|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
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| 100 mg | Get quote |
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T417 (PBX1 inhibitor T417, TCRS-417) is a novel small molecule compound capable of docking to the interface between PBX1 and its cognate DNA target sequence, potently interferes with the PBX1-DNA interaction with IC50 of 6.58 uM.
T417 destabilizes the PBX1-DNA complex, T417 competition of PBX1 protein binding to immobilized PBX1 consensus DNA with IC50 of 5 uM.
T417 selectively suppresses the formation of the PBX1/MEIS2 transcriptional complex, inhibits PBX1 transcriptional activity by hindering its binding to the promoter regions of PBX1 downstream target genes.
T417 (PBX1 inhibitor T417) selectively inhibits carboplatin-resistant tumor cells, and suppresses tumor growth in xenograft models of carboplatin-resistant cancer models.
T417 also is selectively toxic against chr1q-amplified myeloma and solid tumour cells.
| M.Wt | 446.434 | |
| Formula | C25H19FN2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(4-(2-((3,4-dihydroxyphenyl)amino)-2-oxoethoxy)naphthalen-1-yl)-3-fluorobenzamide |
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1. Shen YA, et al. iScience. 2021 Oct 15;24(11):103297.
2. Trasanidis N, et al. Blood. 2022 Jan 11:blood.2021014391.
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