Catalog No.: PC-72727Not For Human Use, Lab Use Only.
T417 (PBX1 inhibitor T417, TCRS-417) is a novel small molecule compound capable of docking to the interface between PBX1 and its cognate DNA target sequence, potently interferes with the PBX1-DNA interaction with IC50 of 6.58 uM.
T417 (PBX1 inhibitor T417, TCRS-417) is a novel small molecule compound capable of docking to the interface between PBX1 and its cognate DNA target sequence, potently interferes with the PBX1-DNA interaction with IC50 of 6.58 uM.
T417 destabilizes the PBX1-DNA complex, T417 competition of PBX1 protein binding to immobilized PBX1 consensus DNA with IC50 of 5 uM.
T417 selectively suppresses the formation of the PBX1/MEIS2 transcriptional complex, inhibits PBX1 transcriptional activity by hindering its binding to the promoter regions of PBX1 downstream target genes.
T417 (PBX1 inhibitor T417) selectively inhibits carboplatin-resistant tumor cells, and suppresses tumor growth in xenograft models of carboplatin-resistant cancer models.
T417 also is selectively toxic against chr1q-amplified myeloma and solid tumour cells.
