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Chemical Structure : T5342126
Catalog No.: PC-63372Not For Human Use, Lab Use Only.
T5342126 is a potent, selective TLR4 inhibitor, inhibits LPS-induced NO production in RAW 264 macrophage cells with IC50 of 27.8 uM.
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T5342126 is a potent, selective TLR4 inhibitor, inhibits LPS-induced NO production in RAW 264 macrophage cells with IC50 of 27.8 uM.
T5342126 shows effectivity in reducing ethanol drinking and inhibiting the activation and proliferation of microglia in both ethanol-dependent and non-dependent mice.
| M.Wt | 457.999 | |
| Formula | C25H32ClN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bajo M, et al. Alcohol. 2016 Sep;51(5):541-8.
2. Chavez SA, et al. J Med Chem. 2011 Jul 14;54(13):4659-69.
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