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T5342126

Chemical Structure : T5342126

CAS No.: 956507-49-6

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T5342126 (T-5342126;T 5342126)

Catalog No.: PC-63372Not For Human Use, Lab Use Only.

T5342126 is a potent, selective TLR4 inhibitor, inhibits LPS-induced NO production in RAW 264 macrophage cells with IC50 of 27.8 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    T5342126 is a potent, selective TLR4 inhibitor, inhibits LPS-induced NO production in RAW 264 macrophage cells with IC50 of 27.8 uM.
    T5342126 shows effectivity in reducing ethanol drinking and inhibiting the activation and proliferation of microglia in both ethanol-dependent and non-dependent mice.

    Physicochemical Properties

    M.Wt 457.999
    Formula C25H32ClN3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(((1-(2-chlorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)-3-(4-ethoxyphenoxy)propan-2-ol

    References

    1. Bajo M, et al. Alcohol. 2016 Sep;51(5):541-8.

    2. Chavez SA, et al. J Med Chem. 2011 Jul 14;54(13):4659-69.

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