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T5342126 hydrochloride

Chemical Structure : T5342126 hydrochloride

CAS No.: 1280194-06-0

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T5342126 hydrochloride (T-5342126;T 5342126)

Catalog No.: PC-63373Not For Human Use, Lab Use Only.

T5342126 hydrochloride is a potent, selective TLR4 inhibitor, inhibits LPS-induced NO production in RAW 264 macrophage cells with IC50 of 27.8 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    T5342126 hydrochloride is a potent, selective TLR4 inhibitor, inhibits LPS-induced NO production in RAW 264 macrophage cells with IC50 of 27.8 uM.
    T5342126 shows effectivity in reducing ethanol drinking and inhibiting the activation and proliferation of microglia in both ethanol-dependent and non-dependent mice.

    Physicochemical Properties

    M.Wt 494.457
    Formula C25H33Cl2N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(((1-(2-chlorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)-3-(4-ethoxyphenoxy)propan-2-ol hydrochloride

    References

    1. Bajo M, et al. Alcohol. 2016 Sep;51(5):541-8.

    2. Chavez SA, et al. J Med Chem. 2011 Jul 14;54(13):4659-69.

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