Catalog No.: PC-45621Not For Human Use, Lab Use Only.
T56-LIMKi (T-5601640) is a specific LIMK2 inhibitor, reduces phosphorylated cofilin (p-cofilin) by LIMK2 but not by LIMK1 and inhibits (IC50=30 uM) the proliferation in NF1−/− MEFs.
T56-LIMKi (T-5601640) is a specific LIMK2 inhibitor, reduces phosphorylated cofilin (p-cofilin) by LIMK2 but not by LIMK1 and inhibits (IC50=30 uM) the proliferation in NF1−/− MEFs.
T56-LIMKi synergizes with salirasib to destabilize the actin cytoskeleton, decreases anchorage-independent cell growth of NF1−/− MEFs.
T56-LIMKi reduces tumor size and p-cofilin levels in a nude mouse Panc-1 xenograft model.
