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Chemical Structure : T56-LIMKi
CAS No.: 924473-59-6
Catalog No.: PC-45621Not For Human Use, Lab Use Only.
T56-LIMKi (T-5601640) is a specific LIMK2 inhibitor, reduces phosphorylated cofilin (p-cofilin) by LIMK2 but not by LIMK1 and inhibits (IC50=30 uM) the proliferation in NF1−/− MEFs.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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T56-LIMKi (T-5601640) is a specific LIMK2 inhibitor, reduces phosphorylated cofilin (p-cofilin) by LIMK2 but not by LIMK1 and inhibits (IC50=30 uM) the proliferation in NF1−/− MEFs.
T56-LIMKi synergizes with salirasib to destabilize the actin cytoskeleton, decreases anchorage-independent cell growth of NF1−/− MEFs.
T56-LIMKi reduces tumor size and p-cofilin levels in a nude mouse Panc-1 xenograft model.
| M.Wt | 389.328 | |
| Formula | C19H14F3N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 36 mg/mL |
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| Chemical Name/SMILES |
5-Isoxazolecarboxamide, 3-methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]- |
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1. Mashiach-Farkash E, et al. Oncotarget. 2012 Jun;3(6):629-39.
2. Rak R, et al. Cell Cycle. 2014;13(9):1360-1.
3. Rak R, et al. Oncoscience. 2014 Jan 1;1(1):39-48.
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