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Chemical Structure : TACH101 L-lysine
CAS No.: 2908753-10-4
Catalog No.: PC-22581Not For Human Use, Lab Use Only.
TACH101 (Zavondemstat, QC8222, TACH 101) L-lysine is a reversible, α-ketoglutarate competitive, selective and potent inhibitor of KDM4 isoforms A-D with IC50 values of 80 nM against all four isoforms.
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| 2 mg | $258 | In stock | |
| 5 mg | $398 | In stock | |
| 10 mg | $588 | In stock | |
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TACH101 (Zavondemstat, QC8222, TACH 101) L-lysine is a reversible, α-ketoglutarate competitive, selective and potent inhibitor of KDM4 isoforms A-D with IC50 values of 80 nM against all four isoforms.
TACH101 weakly inhibits KDM5 family members with IC50 of 140-400 nM, and shows significantly lower potency against KDM2, KDM3, KDM6, and KDM7 family members.
TACH101 demonstrated potent increase of H3K36me3 levels (EC50 <0.001 uM, HTRF) in KYSE-150 cell line engineered to overexpress KDM4C and showed potent anti-proliferative activity in multiple cell lines in OncoPanel.
Sub-micromolar levels of TACH101 induced apoptosis in human colorectal (HT-29), esophageal (KYSE-150), and triple negative breast cancer (MDA-MB-231) cell lines with EC50s of 0.033-0.092 uM.
TACH101 triggered effective tumor growth control in xenograft models including colorectal, esophageal, gastric, breast, and lymphoma with tumor growth inhibition of up to 100%.
| M.Wt | 577.73 | |
| Formula | C32H43N5O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
L-lysine compound with (R)-3-(((7-((4-isopropylphenyl)(methyl)amino)chroman-4-yl)methyl)amino)isonicotinic acid (1:1) |
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1. Chandtip Chandhasin, et al. Anticancer Drugs. 2023 Nov 1;34(10):1122-1131.
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