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Chemical Structure : TAI-1
CAS No.: 1334921-03-7
Catalog No.: PC-61481Not For Human Use, Lab Use Only.
TAI-1 is a potent, small molecule Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=13.48 nM K562 cells).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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TAI-1 is a potent, small molecule Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=13.48 nM K562 cells).
TAI-1 displays 1,000 times improvement in potency compared to INH1, shows nM levels for the majority of the NCI-60 panel.
TAI-1 targets the Hec1-Nek2 pathway, induces chromosomal misalignment and apoptosis, effectively inhibits tumor growth in multiple cancer xenograft models.
| M.Wt | 431.51 | |
| Formula | C24H21N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(4-(4-(4-methoxyphenoxy)-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide |
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1. Huang LY, et al. J Exp Clin Cancer Res. 2014 Jan 9;33:6.
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