TAI-1 is a potent, small molecule Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=13.48 nM K562 cells).
TAI-1 displays 1,000 times improvement in potency compared to INH1, shows nM levels for the majority of the NCI-60 panel.
TAI-1 targets the Hec1-Nek2 pathway, induces chromosomal misalignment and apoptosis, effectively inhibits tumor growth in multiple cancer xenograft models.
