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Chemical Structure : TAI-95
CAS No.: 1438638-83-5
Catalog No.: PC-61482Not For Human Use, Lab Use Only.
TAI-95 (T-1101, TAI 95) is a potent, orally abioavailable Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=14.29-73.65 nM, breast cancer cell lines).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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TAI-95 (T-1101, TAI 95) is a potent, orally abioavailable Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=14.29-73.65 nM, breast cancer cell lines).
TAI-95 (T-1101) demonstrates strong inhibition of in vivo tumor growth of breast cancer models without inducing weight loss or other obvious toxicity.
TAI-95 (T-1101) induces apoptotic cell death, shows activity on MDR cell lines and leads to downregulation of the expression of P-glycoprotein (Pgp),.
TAI-95 (T-1101) also increases the potency of cytotoxic Pgp substrates, including doxorubicin and topotecan.
| M.Wt | 493.6 | |
| Formula | C24H23N5O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[4-(4-{[5-(2-methoxyethoxy)pyrazine-2-yl]thio}-2,6-dimethylphenyl) thiazol-2-yl]isonicotinamide |
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1. Huang LY, et al. Mol Cancer Ther. 2014 Jun;13(6):1419-30.
2. Huang LY, et al. Cancer Chemother Pharmacol. 2014 Sep;74(3):511-20.
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