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Chemical Structure : TAK-071
CAS No.: 1820812-16-5
Catalog No.: PC-35576Not For Human Use, Lab Use Only.
TAK-071 (TAK071) is a potent, selective, low cooperativity (α-value) positive allosteric modulator of muscarinic M1 receptor with inflection point of 2.7 nM in Ca2+ flux assays in CHO-K1 cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
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| 100 mg | Get quote |
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TAK-071 (TAK071) is a potent, selective, low cooperativity (α-value) positive allosteric modulator of muscarinic M1 receptor with inflection point of 2.7 nM in Ca2+ flux assays in CHO-K1 cells.
TAK-071 displays >370-fold M1R selectivity over other muscarinic receptors.
TAK-071 selectively induces afterdepolarization in prefrontal cortical pyramidal neurons significantly ameliorates scopolamine-induced cognitive deficits in rats combined with acetylcholinesterase inhibitor donepezil, with minimizing peripheral cholinergic side effects.
| M.Wt | 421.472 | |
| Formula | C24H24FN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-fluoro-2-[(3S,4S)-4-hydroxytetrahydro-2H-pyran-3-yl]-5-methyl-6-[4-(1H-pyrazol-1-yl)benzyl]-2,3-dihydro-1H-isoindol-1-one |
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1. Sako Y, et al. Neuropsychopharmacology. 2018 Aug 1. doi: 10.1038/s41386-018-0168-8.
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