Chemical Structure : TAK-441
Catalog No.: PC-60477Not For Human Use, Lab Use Only.
A highly potent, orally active hedgehog signaling (Hh) inhibitor with IC50 of 4.4 nM in Gli-luc reporter assays.
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A highly potent, orally active hedgehog signaling (Hh) inhibitor with IC50 of 4.4 nM in Gli-luc reporter assays; suppresses transcription factor Gli1 mRNA expression in tumor-associated stromal tissue and inhibits tumor growth in mouse medulloblastoma allograft model.
Solid Tumors
Phase 1 Discontinued
M.Wt | 576.56 | |
Formula | C28H31F3N4O6 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Ohashi T, et al. Bioorg Med Chem. 2012 Sep 15;20(18):5507-17.
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