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TAK-441

Chemical Structure : TAK-441

CAS No.: 1186231-83-3

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TAK-441 (TAK 441;TAK441)

Catalog No.: PC-60477Not For Human Use, Lab Use Only.

TAK-441 is a highly potent, orally active hedgehog signaling (Hh) inhibitor with IC50 of 4.4 nM in Gli-luc reporter assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TAK-441 is a highly potent, orally active hedgehog signaling (Hh) inhibitor with IC50 of 4.4 nM in Gli-luc reporter assays.
TAK-441 suppresses transcription factor Gli1 mRNA expression in tumor-associated stromal tissue and inhibits tumor growth in mouse medulloblastoma allograft model.

Physicochemical Properties

M.Wt 576.56
Formula C28H31F3N4O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-Ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

References

1. Ohashi T, et al. Bioorg Med Chem. 2012 Sep 15;20(18):5507-17.

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