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Chemical Structure : TAK-925
Catalog No.: PC-72749Not For Human Use, Lab Use Only.
TAK-925 (Danavorexton) is a potent, selective, and brain-penetrant Orexin 2 receptor (OX2R) agonist with EC50 of 5.5 nM, no significant inhibition on OX1R (IC50>100 uM).
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TAK-925 (Danavorexton) is a potent, selective, and brain-penetrant Orexin 2 receptor (OX2R) agonist with EC50 of 5.5 nM, no significant inhibition on OX1R (IC50>100 uM).
TAK-925 also showed good selectivity against 106 off-target enzymes and receptors.
TAK-925 produced wake-promoting effects in mice during the sleep phase, being developed for the treatment of narcolepsy and other related disorders.
| M.Wt | 424.556 | |
| Formula | C21H32N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fujimoto T, et al. ACS Med Chem Lett. 2022 Feb 4;13(3):457-462.
2. Yukitake H, et al. Pharmacol Biochem Behav. 2019 Dec;187:172794.
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