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TAK-925

Chemical Structure : TAK-925

CAS No.: 2114324-48-8

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TAK-925 (Danavorexton, TAK925)

Catalog No.: PC-72749Not For Human Use, Lab Use Only.

TAK-925 (Danavorexton) is a potent, selective, and brain-penetrant Orexin 2 receptor (OX2R) agonist with EC50 of 5.5 nM, no significant inhibition on OX1R (IC50>100 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TAK-925 (Danavorexton) is a potent, selective, and brain-penetrant Orexin 2 receptor (OX2R) agonist with EC50 of 5.5 nM, no significant inhibition on OX1R (IC50>100 uM).
    TAK-925 also showed good selectivity against 106 off-target enzymes and receptors.
    TAK-925 produced wake-promoting effects in mice during the sleep phase, being developed for the treatment of narcolepsy and other related disorders.

    Physicochemical Properties

    M.Wt 424.556
    Formula C21H32N2O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-Piperidinecarboxylic acid, 3-[(methylsulfonyl)amino]-2-[[(cis-4-phenylcyclohexyl)oxy]methyl]-, methyl ester, (2R,3S)-

    References

    1. Fujimoto T, et al. ACS Med Chem Lett. 2022 Feb 4;13(3):457-462.

    2. Yukitake H, et al. Pharmacol Biochem Behav. 2019 Dec;187:172794.

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