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TAK0104

Chemical Structure : TAK0104

CAS No.: 296792-25-1

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TAK0104 (TAK-0104)

Catalog No.: PC-28716Not For Human Use, Lab Use Only.

TAK0104 is a compound targeting T. gondii adenosine kinase (TgAK), inhibits intracellular parasite growth with IC50 of 322.6 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TAK0104 is a compound targeting T. gondii adenosine kinase (TgAK), inhibits intracellular parasite growth with IC50 of 322.6 nM.
TAK0104 induces intracellular ATP depletion in infected host cells.
TAK0104-mediated growth inhibition is associated with disruption of purine salvage-associated metabolism.
TAK0104 induces intracellular oxidative stress in T. gondii-infected host cells.
TAK0104 induces mitochondrial membrane depolarization in infected host cells.

Physicochemical Properties

M.Wt 297.38
Formula C16H15N3OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-amino-2-{[(2-methyl-1-naphthyl)methyl]thio}-4-pyrimidinol

References

1. Yasser Alraey, et al. Mol Biochem Parasitol. 2026 Oct 30:268:111790.

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