TAP311 | CETP inhibitor | Probechem Biochemicals

Chemical Structure : TAP-311

TAP-311 (TAP311)

Catalog No.: PC-62014Not For Human Use, Lab Use Only.

TAP-311 (TAP311) is a novel potent and selective CETP inhibitor with plasma IC50 of 62 nM.

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Biological Activity

TAP-311 (TAP311) is a novel potent and selective CETP inhibitor with plasma IC50 of 62 nM.
TAP-311 displays >170-fold selectivity over CYPs, and has excellent pharmacokinetics in rats and robust efficacy in hamsters.
TAP-311 shows substantially reduced lipophilicity with only modest distribution into adipose tissue, and retains potency in hypertriglyceridemic plasma in vitro and in vivo.
TAP-311 does not increase blood pressure or plasma aldosterone levels in vivo, in contrast to torcetrapib (Cat# PC-42892).

Physicochemical Properties

M.Wt	710.72
Formula	C34H40F6N6O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((4-((3,5-bis(trifluoromethyl)benzyl)(5-(1-methyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)-2,6-diethylpiperidine-1-carbonyl)oxy)cyclohexane-1-carboxylic acid

References

1. Yamada K, et al. J Med Chem. 2017 Oct 26;60(20):8466-8481.

TAP-311 (TAP311)

Biological Activity

Physicochemical Properties

References

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