Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : TAS05567
Catalog No.: PC-63503Not For Human Use, Lab Use Only.
TAS05567 (TAS-5567) is a novel potent, selective, orally available Spleen tyrosine kinase (Syk) inhibitor with IC50 of 0.37 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
TAS05567 (TAS-5567) is a novel potent, selective, orally available Spleen tyrosine kinase (Syk) inhibitor with IC50 of 0.37 nM.
TAS05567 shows >70% inhibition of Syk and 4 other kinases in a panel of 192 kinases, more selective and potent than R406.
TAS05567 suppresses induction of BLNK phosphorylation by anti-IgM in Ramos cells (IC50=1.8 nM).
TAS05567 inhibits BCR-dependent signal transduction in Ramos cells, FcγR-mediated TNF-α production in THP-1 cells, and FcεR-mediated histamine release from RBL-2H3 cells.
TAS05567 suppresses hind-paw swelling in a dose-dependent manner, markedly reduces histopathologic scores in rheumatoid arthritis models.
| M.Wt | 439.524 | |
| Formula | C21H29N9O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Hayashi H, et al. J Pharmacol Exp Ther. 2018 May 4. pii: jpet.118.248153.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
