Catalog No.: PC-72962Not For Human Use, Lab Use Only.
TASIN-1 (Truncated APC selective inhibitor-1) is a small molecule that specifically kills cells with APC truncations but spares normal and cancer cells with wild-type APC, inhibits emopamil-binding protein (EBP).
TASIN-1 (Truncated APC selective inhibitor-1) is a small molecule that specifically kills cells with APC truncations but spares normal and cancer cells with wild-type APC, inhibits emopamil-binding protein (EBP).
TASIN-1 exhibited potent and selective toxicity toward DLD1 cells (IC50 = 70 nM) but not toward HCT116 cells (IC50 > 50 μM).
TASIN-1 decreased the endogenous cholesterol biosynthesis rate in APC-truncated HT29 and DLD1 cells but not in APC WT HCT116 and RKO cells, TASIN-1 exerts its cytotoxicity through inhibition of cholesterol biosynthesis.
TASIN-1 inhibits emopamil-binding protein (EBP) or 24-dehydrocholesterol reductase (DHCR24).
