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TBBD

Chemical Structure : TBBD

CAS No.: 476-66-4

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TBBD (Ellagic acid)

Catalog No.: PC-35041Not For Human Use, Lab Use Only.

TBBD (Ellagic acid) is a specific inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1, PRMT4) that selectively inhibits methylation at arginine 17 of histone H3 (H3R17).

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Biological Activity

TBBD (Ellagic acid) is a specific inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1, PRMT4) that selectively inhibits methylation at arginine 17 of histone H3 (H3R17).
TBBD shows no significant effect on the HMTase activity of G9a, as well as on the HAT activity of p300/CBP-associated factor.

Physicochemical Properties

M.Wt 302.194
Formula C14H6O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,3,7,8-tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione

References

1. Selvi BR, et al. J Biol Chem. 2010 Mar 5;285(10):7143-52.

2. Hatanaka Y, et al. Cell Rep. 2017 Sep 19;20(12):2756-2765.

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