TC-2153 (TC2153) is a specific, small moelcule inhibitor of neuron-specific tyrosine phosphatase STEP with IC50 of 24.6 nM.
TC-2153 increases tyrosine phosphorylation of STEP substrates ERK1/2, Pyk2, and GluN2B, and exhibits no toxicity in cortical cultures.
TC-2153 shows specificity towards STEP compared to several other tyrosine phosphatases.
TC-2153 improves cognitive deficits in 3xTg-AD mice, with no change in beta amyloid and phospho-tau levels.
