TC-PTP inhibitor 8

Chemical Structure : TC-PTP inhibitor 8

Catalog No.: PC-20597Not For Human Use, Lab Use Only.

TC-PTP inhibitor 8 is a potent, selective, cell-active inhibitor of TC-PTP with IC50 of 9.2 nM, and Ki of 4.3 nM.

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Biological Activity

TC-PTP inhibitor 8 is a potent, selective, cell-active inhibitor of TC-PTP with IC50 of 9.2 nM, and Ki of 4.3 nM.
TC-PTP inhibitor 8 displays 8-fold selectivity for TC-PTP over its closest homologue PTP1B (Ki=34 nM).
TC-PTP inhibitor 8 is more than 200-fold selective versus a panel of PTPs including the cytosolic PTPs, SHP2, Lyp, HePTP, PTP-Meg2, and FAP1, the receptor-like PTPs, CD45, LAR, and PTPα, the dual specificity phosphatase VHR, VHX, and CDC14A, and low molecular weight PTP.
TC-PTP inhibitor 8 (5-50 nM)enhanced EGFR phosphorylation in a dose-dependent fashion in PTP1B−/− mouse embryo fibroblast cells, dose-dependently increases pSrc416 phosphorylation with no significant change in pSrc527.

Physicochemical Properties

M.Wt	898.00
Formula	C46H62F2N5O9P
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((4-((S)-3-(((S)-1-amino-6-(4-ethylbenzamido)-1-oxohexan-2-yl)amino)-2-((S)-2-(2-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)acetamido)-3-phenylpropanamido)-3-oxopropyl)phenyl)methylene)bis(phosphonofluoridic acid)

References

1. Zhang S, et al. J Am Chem Soc. 2009 Sep 16;131(36):13072-9.