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Chemical Structure : TC-PTP inhibitor 8
Catalog No.: PC-20597Not For Human Use, Lab Use Only.
TC-PTP inhibitor 8 is a potent, selective, cell-active inhibitor of TC-PTP inhibitor with IC50 of 9.2 nM, and Ki of 4.3 nM.
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TC-PTP inhibitor 8 is a potent, selective, cell-active inhibitor of TC-PTP inhibitor with IC50 of 9.2 nM, and Ki of 4.3 nM.
TC-PTP inhibitor 8 displays 8-fold selectivity for TC-PTP over its closest homologue PTP1B (Ki=34 nM).
TC-PTP inhibitor 8 is more than 200-fold selective versus a panel of PTPs including the cytosolic PTPs, SHP2, Lyp, HePTP, PTP-Meg2, and FAP1, the receptor-like PTPs, CD45, LAR, and PTPα, the dual specificity phosphatase VHR, VHX, and CDC14A, and low molecular weight PTP.
TC-PTP inhibitor 8 (5-50 nM)enhanced EGFR phosphorylation in a dose-dependent fashion in PTP1B−/− mouse embryo fibroblast cells, dose-dependently increases pSrc416 phosphorylation with no significant change in pSrc527.
| M.Wt | 898.00 | |
| Formula | C46H62F2N5O9P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhang S, et al. J Am Chem Soc. 2009 Sep 16;131(36):13072-9.
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