TC-PTP inhibitor 8

Chemical Structure : TC-PTP inhibitor 8

Catalog No.: PC-20597Not For Human Use, Lab Use Only.

TC-PTP inhibitor 8 is a potent, selective, cell-active inhibitor of TC-PTP inhibitor with IC50 of 9.2 nM, and Ki of 4.3 nM.

Packing	Price	Stock	Quantity
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

TC-PTP inhibitor 8 is a potent, selective, cell-active inhibitor of TC-PTP inhibitor with IC50 of 9.2 nM, and Ki of 4.3 nM.
TC-PTP inhibitor 8 displays 8-fold selectivity for TC-PTP over its closest homologue PTP1B (Ki=34 nM).
TC-PTP inhibitor 8 is more than 200-fold selective versus a panel of PTPs including the cytosolic PTPs, SHP2, Lyp, HePTP, PTP-Meg2, and FAP1, the receptor-like PTPs, CD45, LAR, and PTPα, the dual specificity phosphatase VHR, VHX, and CDC14A, and low molecular weight PTP.
TC-PTP inhibitor 8 (5-50 nM)enhanced EGFR phosphorylation in a dose-dependent fashion in PTP1B−/− mouse embryo fibroblast cells, dose-dependently increases pSrc416 phosphorylation with no significant change in pSrc527.

Physicochemical Properties

M.Wt	898.00
Formula	C46H62F2N5O9P
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(N)[C@H](CCCCNC(C1=CC=C(CC)C=C1)=O)NC([C@H](CC2=CC=C(C(P(O)(F)=O)P(O)(F)=O)C=C2)NC([C@H](CC3=CC=CC=C3)NC(CO[C@@H]4[C@@H](C(C)C)CC[C@H](C)C4)=O)=O)=O

References

1. Zhang S, et al. J Am Chem Soc. 2009 Sep 16;131(36):13072-9.