Chemical Structure : TCIP3
CAS No.:
3067681-36-8
TCIP3
Catalog No.: PC-27203Not For Human Use, Lab Use Only.
TCIP3 is a cell-permeable lysine acetyltransferase TCIP (KAT-TCIP) and bivalent molecular glue degrader that binds dually to p300/CBP and BCL6, redirects p300/CBP to BCL6, exhibits potent anti-proliferative effect in DLBCL cells.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TCIP3 is a cell-permeable lysine acetyltransferase TCIP (KAT-TCIP) and bivalent molecular glue degrader that binds dually to p300/CBP and BCL6, redirects p300/CBP to BCL6, exhibits potent anti-proliferative effect in DLBCL cells.
TCIP3 inhibits the proliferation of SUDHL5 DLBCL cells with an average IC50 of 0.8 nM.
TCIP3 inhibits the viability of high-BCL6 lines SUDHL5, K422, DB, and DAUDI at comparable potencies (1.2 nM, 4.0 nM, 9.8 nM, and 6.9 nM, respectively), approximately 200 to 1000 times greater than the co-treatment of the inhibitors GNE-781 and BI-3812.
TCIP3 shows dual engagement with p300/CBP and BCL6.
TCIP3 induces redirection of p300/CBP acetyltransferase activity to BCL6-proximal DNA.
TCIP3 acts as a molecular glue, stabilizing interactions between p300/CBP and BCL6.
Physicochemical Properties
|
M.Wt
|
1177.76
|
|
Formula
|
C58H71ClF2N16O7
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
5H-Pyrazolo[4,3-c]pyridine-5-carboxamide, 1-[1-[3-[4-[[1-[5-chloro-4-[[1,2-dihydro-8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxo-6-quinolinyl]amino]-2-pyrimidinyl]-4-piperidinyl]carbonyl]-1-piperazinyl]-1-oxopropyl]-4-piperidinyl]-3-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1H-pyrazol-4-yl)-1(2H)-quinolinyl]-1,4,6,7-tetrahydro-N-methyl-
|
References
1. Meredith N Nix, et al. bioRxiv [Preprint]. 2025 Mar 17:2025.03.14.643404.
Contact Us
sales@probechem.com
