TCL-Ester | Rpn-13 inhibitor | Probechem Biochemicals

Chemical Structure : TCL-Ester

TCL-Ester (TCL-1 Ester)

Catalog No.: PC-21189Not For Human Use, Lab Use Only.

TCL-Ester is the cell-permeable derivative of TCL-1, a non-covalent ligand targeting the Pru domain of Rpn-13.

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Biological Activity

TCL-Ester is the cell-permeable derivative of TCL-1, a non-covalent ligand targeting the Pru domain of Rpn-13.
TCL-Ester (25-50 uM, 24 h) is toxic against hematological cancer cell lines that are sensitive to proteasome inhibition.
TCL-Ester is a useful scaffold can be modified and still retain binding to Rpn-13's Pru domain.

Physicochemical Properties

M.Wt	505.82
Formula	C21H18BrClN4O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 2-(3-(4-bromobenzyl)-6-(4-chlorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl)acetate

References

1. Loy CA, et al. Bioorg Med Chem Lett. 2023 Sep 13:129485.

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TCL-Ester (TCL-1 Ester)

Biological Activity

Physicochemical Properties

References

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