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Chemical Structure : TCL-Ester
Catalog No.: PC-21189Not For Human Use, Lab Use Only.
TCL-Ester is the cell-permeable derivative of TCL-1, a non-covalent ligand targeting the Pru domain of Rpn-13.
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TCL-Ester is the cell-permeable derivative of TCL-1, a non-covalent ligand targeting the Pru domain of Rpn-13.
TCL-Ester (25-50 uM, 24 h) is toxic against hematological cancer cell lines that are sensitive to proteasome inhibition.
TCL-Ester is a useful scaffold can be modified and still retain binding to Rpn-13's Pru domain.
| M.Wt | 505.82 | |
| Formula | C21H18BrClN4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Loy CA, et al. Bioorg Med Chem Lett. 2023 Sep 13:129485.
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