TCS401 |CAS:243966-09-8 Probechem Biochemicals

Chemical Structure : TCS401

CAS No.: 243966-09-8

TCS401 (TCS-401, TCS 401)

Catalog No.: PC-42970Not For Human Use, Lab Use Only.

TCS-401 (TCS401) is a potent, selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) with Ki of 0.29 uM, weakly inhibits the protein phosphatases CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1, and LAR D1D2 with Ki of 59, 560, 1,100, >2,000, >2,000, and >2,000 uM.

Packing	Price	Stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$358	In stock
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Biological Activity

TCS-401 (TCS401) is a potent, selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) with Ki of 0.29 uM, weakly inhibits the protein phosphatases CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1, and LAR D1D2 with Ki of 59, 560, 1,100, >2,000, >2,000, and >2,000 uM.
TCS-401 dose dependently inhibits the RPTC-Sup-induced reduction of fibronectin and α-SMA.
TCS-401 reduces RPTC-Sup-induced EGFR dephosphorylation and reverses the levels of fibronectin and α-SMA in renal fibroblasts.

Physicochemical Properties

M.Wt	306.7227
Formula	C10H11ClN2O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: 11 mg/mL
Chemical Name/SMILES	Thieno[2,3-c]pyridine-3-carboxylic acid, 2-[(carboxycarbonyl)amino]-4,5,6,7-tetrahydro-, hydrochloride (1:1)

References

1. Iversen LF, et al. J Biol Chem. 2000 Apr 7;275(14):10300-7.

2. Ponnusamy M, et al. Am J Physiol Renal Physiol. 2013 Mar 15;304(6):F698-709.

3. Du ZD, et al. Mol Vis. 2015 May 1;21:523-31. eCollection 2015.

TCS401 (TCS-401, TCS 401)

Biological Activity

Physicochemical Properties

References

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