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TD-1

Chemical Structure : TD-1

CAS No.: 1621694-21-0

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TD-1 (Hemoglobin modulator TD-1)

Catalog No.: PC-62380Not For Human Use, Lab Use Only.

Hemoglobin modulator TD-1 (TD-1) is a novel allosteric effector of hemoglobin that increases hemoglobin oxygen affinity and reduces SS erythrocyte sickling.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Hemoglobin modulator TD-1 (TD-1) is a novel allosteric effector of hemoglobin that increases hemoglobin oxygen affinity and reduces SS erythrocyte sickling.
    TD-1 increases the oxygen affinity of sickle hemoglobin and inhibits in vitro hypoxia-induced sickling of red blood cells in patients with sickle cell disease without causing hemolysis.
    TD-1 is a novel lead molecule for the treatment of patients with sickle cell disease.

    Physicochemical Properties

    M.Wt 468.506
    Formula C20H16N6O4S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Di(5-(2,3-dihydro-1,4-benzodioxin-2-yl)-4H-1,2,4-triazol-3-yl)disulfide

    References

    1. Nakagawa A, et al. ACS Chem Biol. 2014 Oct 17;9(10):2318-25.

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