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TDI-11904

Chemical Structure : TDI-11904

CAS No.: 3056015-44-9

TDI-11904 (TDI 11904)

Catalog No.: PC-72366Not For Human Use, Lab Use Only.

TDI-11904 is a highly potent, and peripherally active EZH2 inhibitor with IC50 of 0.9 nM, inhibits H3K27me3 with IC50 of 6.0 nM in cellular EZH2 inhibition assay.

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    Biological Activity

    TDI-11904 is a highly potent, and peripherally active EZH2 inhibitor with IC50 of 0.9 nM, inhibits H3K27me3 with IC50 of 6.0 nM in cellular EZH2 inhibition assay.

    Physicochemical Properties

    M.Wt 507.430
    Formula C23H24Cl2N4O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    6,9-dichloro-7-(3,5-dimethylisoxazol-4-yl)-1-methyl-4-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one

    References

    1. Rui Liang, et al. ACS Med Chem Lett. 2022 Feb 10;13(3):377-387.

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