TDI-11904 | EZH2 inhibitor | Probechem Biochemicals

Chemical Structure : TDI-11904

TDI-11904 (TDI 11904)

Catalog No.: PC-72366Not For Human Use, Lab Use Only.

TDI-11904 is a highly potent, and peripherally active EZH2 inhibitor with IC50 of 0.9 nM, inhibits H3K27me3 with IC50 of 6.0 nM in cellular EZH2 inhibition assay.

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Biological Activity

TDI-11904 is a highly potent, and peripherally active EZH2 inhibitor with IC50 of 0.9 nM, inhibits H3K27me3 with IC50 of 6.0 nM in cellular EZH2 inhibition assay.

Physicochemical Properties

M.Wt	507.430
Formula	C23H24Cl2N4O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6,9-dichloro-7-(3,5-dimethylisoxazol-4-yl)-1-methyl-4-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one

References

1. Rui Liang, et al. ACS Med Chem Lett. 2022 Feb 10;13(3):377-387.

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TDI-11904 (TDI 11904)

Biological Activity

Physicochemical Properties

References

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