TDI-6118 | EZH2 inhibitor | Probechem Biochemicals

Chemical Structure : TDI-6118

Catalog No.: PC-72365Not For Human Use, Lab Use Only.

TDI-6118 is a potent, selective brain-penetrant EZH2 inhibitor with IC50 of 14 nM, inhibits cellular H3K27me with IC50 of 580 nM.

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Biological Activity

TDI-6118 is a potent, selective brain-penetrant EZH2 inhibitor with IC50 of 14 nM, inhibits cellular H3K27me with IC50 of 580 nM.

M.Wt	460.355
Formula	C23H23Cl2N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,8-dichloro-7-(3,5-dimethylisoxazol-4-yl)-2-((1,4,6-trimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one

1. Rui Liang, et al. ACS Med Chem Lett. 2022 Feb 10;13(3):377-387.