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TDI-6118

Chemical Structure : TDI-6118

CAS No.: 3056015-28-9

TDI-6118 (TDI 6118, TDI6118)

Catalog No.: PC-72365Not For Human Use, Lab Use Only.

TDI-6118 is a potent, selective brain-penetrant EZH2 inhibitor with IC50 of 14 nM, inhibits cellular H3K27me with IC50 of 580 nM.

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    Biological Activity

    TDI-6118 is a potent, selective brain-penetrant EZH2 inhibitor with IC50 of 14 nM, inhibits cellular H3K27me with IC50 of 580 nM.
     

    Physicochemical Properties

    M.Wt 460.355
    Formula C23H23Cl2N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    5,8-dichloro-7-(3,5-dimethylisoxazol-4-yl)-2-((1,4,6-trimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one

    References

    1. Rui Liang, et al. ACS Med Chem Lett. 2022 Feb 10;13(3):377-387.

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