TDI6245 | Pf20S inhibitor | Probechem Biochemicals

Chemical Structure : TDI6245

TDI6245 (TDI-6245)

Catalog No.: PC-27565Not For Human Use, Lab Use Only.

TDI6245 (TDI-6245) is a highly potent Plasmodium 20S proteasome core (Pf20S) β5 inhibitor with IC50 of 110 nM, shows potent anti-Pf 3D7 activity with EC50 of 38 nM, has >60 fold selectivity over human c-20S β5c and human i-20S β5i.

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Biological Activity

Physicochemical Properties

M.Wt	500.61
Formula	C25H32N4O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N4-(tert-butyl)-2-((4-methylphenyl)sulfonamido)-N1-(2-(1-oxoisoindolin-2-yl)ethyl)succinamide

References

1. Hao Zhang, et al. ACS Omega. 2026 Jul 21;11(30):45549-45559.

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TDI6245 (TDI-6245)

Biological Activity

Physicochemical Properties

References

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