Chemical Structure : TDRL-505
CAS No.:
313405-38-8
TDRL-505
(TDRL505)
Catalog No.: PC-25661Not For Human Use, Lab Use Only.
TDRL-505 is a small molecule inhibitor of Replication protein A (RPA) with IC50 of 13 uM, inhibits RPA's DNA binding activity targeting DBD-A and B in the 70 kDa subunit of RPA.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TDRL-505 is a small molecule inhibitor of Replication protein A (RPA) with IC50 of 13 uM, inhibits RPA's DNA binding activity targeting DBD-A and B in the 70 kDa subunit of RPA.
TDRL-505 decreases cell viability and nuclear RPA staining without induction of apoptosis and degradation of RPA.
TDRL-505 affects cell cycle progression and DNA replication.
TDRL-505 acts synergistically with both cisplatin and etoposide in H460 cells.
TDRL-505 inhibits RPA-DNA interactions in vitro, blocks cell entry into S-phase and results in a cytotoxic/cytostatic response.
Physicochemical Properties
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M.Wt
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530.80
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Formula
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C24H21BrClN3O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(3-(4-bromophenyl)-5-(2-chloro-7-ethoxyquinolin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid
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References
1. Mishra AK, et al. Biochem Pharmacol. 2015 Jan 1;93(1):25-33.
2. Sarah C Shuck, et al. Cancer Res. 2010 Apr 15;70(8):3189-98.
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