TDRL-551 | RPA inhibitor | Probechem Biochemicals

Chemical Structure : TDRL-551

CAS No.: 1644626-43-6

TDRL-551 (TDRL551, Replication Protein A inhibitor)

Catalog No.: PC-20337Not For Human Use, Lab Use Only.

TDRL-551 (TDRL551) is a small molecule Replication Protein A (RPA) inhibitor targeting the Replication Protein A-DNA interaction with IC50 of 18 uM.

Packing	Price	Stock
5 mg	$218	In stock
10 mg	$358	In stock
25 mg	$598	In stock
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Biological Activity

TDRL-551 (TDRL551) is a small molecule Replication Protein A (RPA) inhibitor targeting the Replication Protein A-DNA interaction with IC50 of 18 uM.
TDRL-551 exhibits single agent anti-cancer activity in the A2780 EOC cell line using clonogenic survival assays with IC50 of 25 uM.
TDRL-551 is synergistic with DNA damaging chemotherapeutic agent in platinum sensitive A2780 cell line.
TDRL-551 displays single agent anti-cancer activity and sensitizes NSCLC tumors to platinum based treatment in vivo.

Physicochemical Properties

M.Wt	591.83
Formula	C25H23ClIN3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(2-Chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo-1H-pyrazole-1-pentanoic acid

References

1. Mishra AK, et al. Biochem Pharmacol. 2015 Jan 1;93(1):25-33.

2. Gavande NS, et al. ACS Med Chem Lett. 2020 Jan 2;11(6):1118-1124.

TDRL-551 (TDRL551, Replication Protein A inhibitor)

Biological Activity

Physicochemical Properties

References

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