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TDZD-8

Chemical Structure : TDZD-8

CAS No.: 327036-89-5

TDZD-8 (TDZD8, GSK-3β Inhibitor I, NP 01139)

Catalog No.: PC-42787Not For Human Use, Lab Use Only.

TDZD-8 (GSK-3β Inhibitor I, NP 01139) is a potent, selective, non-ATP competitive GSK-3β inhibitor with IC50 of 2 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TDZD-8 (GSK-3β Inhibitor I, NP 01139) is a potent, selective, non-ATP competitive GSK-3β inhibitor with IC50 of 2 uM.
TDZD-8 displays no activity against PKA, CK-2, PKC, and CDK1 (IC50>100 uM).
TDZD-8 reduces the colonic inflammation induced by TNBS in vivo, also prevents 6-OHDA-induced neuronal cell death.

Physicochemical Properties

M.Wt 222.2636
Formula C10H10N2O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)-

References

1. Martinez A, et al. J Med Chem. 2002 Mar 14;45(6):1292-9.

2. Whittle BJ, et al. Br J Pharmacol. 2006 Mar;147(5):575-82.

3. Dugo L, et al. Crit Care Med. 2005 Sep;33(9):1903-12.

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