Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : TERT inhibitor NU-1
Catalog No.: PC-20452Not For Human Use, Lab Use Only.
TERT inhibitor NU-1 is an irreversible telomerase reverse transcriptase (TERT), targets the non-homologous end joining (NHEJ) DSB repair pathway.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
TERT inhibitor NU-1 is an irreversible telomerase reverse transcriptase (TERT), targets the non-homologous end joining (NHEJ) DSB repair pathway.
NU-1 decreases cell viability in telomerase-positive human cancer cell lines, including breast cancer MCF7 (LD50=21 uM), impacts DNA damage pathway gene expression.
NU-1 enhances the chemo-sensitivity of telomerase-positive cancer cells.
NU-1 induces radiosensitivity and cellular senescence, induces persistent DNA damage foci and delays double-strand break repair after irradiation in telomerase-positive cells.
NU-1 dramatically enhanced the effects of radiation, leading to immune-dependent tumor elimination in CT26 tumors in BALB/c mice.
| M.Wt | 419.43 | |
| Formula | C21H23F2N3O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Yue Liu, et al. Cell Chem Biol. 2022 Oct 20;29(10):1517-1531.e7.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
