Chemical Structure : TES-1025
CAS No.: 1883602-21-8
Catalog No.: PC-35239Not For Human Use, Lab Use Only.
TES-1025 (TES1025) is a potent, selective inhibitor of human ACMSD (α-Amino-β-carboxymuconate-ε-semialdehyde decarboxylase) with IC50 of 13 nM, increases NAD+ levels in cellular systems.
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TES-1025 (TES1025) is a potent, selective inhibitor of human ACMSD (α-Amino-β-carboxymuconate-ε-semialdehyde decarboxylase) with IC50 of 13 nM, increases NAD+ levels in cellular systems.
TES-1025 demonstrates suitable overall balance of good physicochemical properties and in vitro safety profile.
TES-1025 modulates intracellular NAD+ levels with consequent in vivo enhancement of de novo NAD+ biosynthesis via ACMSD target engagement.
| M.Wt | 383.44 | |
| Formula | C18H13N3O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(3-(((5-cyano-6-oxo-4-(thiophen-2-yl)-1,6-dihydropyrimidin-2-yl)thio)methyl)phenyl)acetic acid |
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1. Pellicciari R, et al. J Med Chem. 2018 Feb 8;61(3):745-759.

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