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TES-1025

Chemical Structure : TES-1025

CAS No.: 1883602-21-8

TES-1025 (TES1025)

Catalog No.: PC-35239Not For Human Use, Lab Use Only.

TES-1025 (TES1025) is a potent, selective inhibitor of human ACMSD (α-Amino-β-carboxymuconate-ε-semialdehyde decarboxylase) with IC50 of 13 nM, increases NAD+ levels in cellular systems.

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Biological Activity

TES-1025 (TES1025) is a potent, selective inhibitor of human ACMSD (α-Amino-β-carboxymuconate-ε-semialdehyde decarboxylase) with IC50 of 13 nM, increases NAD+ levels in cellular systems.
TES-1025 demonstrates suitable overall balance of good physicochemical properties and in vitro safety profile.
TES-1025 modulates intracellular NAD+ levels with consequent in vivo enhancement of de novo NAD+ biosynthesis via ACMSD target engagement.

Physicochemical Properties

M.Wt 383.44
Formula C18H13N3O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(3-(((5-cyano-6-oxo-4-(thiophen-2-yl)-1,6-dihydropyrimidin-2-yl)thio)methyl)phenyl)acetic acid

References

1. Pellicciari R, et al. J Med Chem. 2018 Feb 8;61(3):745-759.

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